TL;DR:
If you are looking for a remote island experience with white beaches and crystal blue water, this is a great destination.
Cayo Coco:
Cayo Coco is a very remote area of Cuba with very little around it. It is very quiet with limited activities outside of the resorts.
Where I Stayed:
Melia Cayo Coco
This is a medium sized 5-star resort. The food was above-average, or very good for Cuban standards. Amenities are well maintained, but limited in quantity. Rooms sometimes have water issues and the beds were ok to sleep on. Luckily you won’t spend too much time in the rooms. Overall, the resort was great for Cuban standards, quiet and safe.
*As an added bonus, if you stay at the Melia Cayo Coco you get access to two other 4-star Melia resorts. There is a paid (very cheap) shuttle between each one and each offers its own variety of activities and beaches.
Recommended Activities:
Being so remote, if your resort offers bike rentals, be sure to go for a bike ride on the empty roads. It’s a rare experience anywhere in the world.
At night, there is an off-resort night club in a cave (with bats!) that’s a unique experience. The price includes unlimited drinks, but be prepared to wait in line (or make friends with a bartender at the beginning with a nice tip to help speed things up).